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The tripeptide glycyl-L-histidyl-L-lysine was first isolated from human serum by Pickart and Thayer, whose 1973 paper in Biochemical and Biophysical Research Communications documented that the synthetic tripeptide prolongs survival of normal liver cells at nanomolar concentrations, establishing the foundational observation that small peptide fragments in circulation have tissue-maintenance functions

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These cells are glued together by proteins called Tight Junctions. When you eat a poor diet, take antibiotics, or live under chronic stress, this glue breaks down